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Research Involving Aspects of Medicinal
Chemistry, Structural Biology, Carbohydrate Enzymology
and Natural Products discovery Funding for
summer research
Undergraduate
opportunities
An ideal
opportunity to develop skills in addition to those taught in undergraduate
courses that will make you stand out and potentially have your name on a
scientific manuscript. The
lab actively welcomes motivated and talented undergraduates to join them as
volunteers during the academic year helping-out with laboratory chores and
experiments, or as summer students working in conjunction with graduate
students and post-doctoral fellows on a small research project. Undergraduate science students are encouraged to apply for an
NSERC summer student award to cover the cost of their summer experience in
January. Broadly speaking, chemistry, biochemistry and microbiology
undergraduate students will benefit from a summer working in the Jakeman
laboratory. Undergraduate pharmacy students are encouraged to apply to the
summer research program organized within the Undergraduate co-op students with documented research experience
using skills below will be at an advantage. Students
with documented practical skills and experience relating to techniques used
in the Jakeman laboratory may be offered funding directly through the
research laboratory. Volunteering throughout the school year (> 5 hrs per
week) may convince the laboratory to take you on during the summer full-time.
Students with a strong scientific research interest will obviously be at an
advantage. Graduate student
opportunities
Graduate
students are enrolled in the Department of Chemistry graduate program.
Potential students should contact Giselle.Andrews@dal.ca
for an application package. Stipends for graduate students are available
through the federal funding agencies NSERC or CIHR for Canadian citizens.
These applications are run through the Department of Chemistry. The
Nova Scotia Health Research Foundation
funds graduate students applying science towards health research. The
registration deadline is 1st march and application deadline is the 1st May,
and involves writing a detailed research proposal of 5 pages. The
Cancer Research Training
Program also offers scholarships and deadlines are quarterly. The
application involves writing a detailed research proposal of 5 pages. If
you are interested in applying to the NSHRF or the CRTP then contact Dr.
Jakeman for further details. Post-doctoral
fellowships
Applications
for the Killam Trust post-doctoral awards at Dalhousie University
are accepted until the middle of December when units rank potential
candidates. Outstanding applicants, (within 2 years of receiving their Ph.D.)
with several first author published publications in good journals, who are
interested in Dr. Jakeman’s research are encouraged
to contact him for more details. A written five-page research proposal is
required. Awardees are notified in February, and fellowships maybe initiated
after 1st September. Example skill
sets actively used by students within the Jakeman laboratory
Familiarity with word, powerpoint and excel is expected, as is exceptional time management skills, accurate laboratory recording skills and good communication with others. Chemistry
Wet-lab
synthetic organic chemistry, experience of using a vacuum / nitrogen
manifold, flash column chromatography, TLC, HPLC, ion-exchange chromatography
of water-soluble compounds Hands on
liquid state 1H and 13C NMR spectroscopy and the
analysis of the structures of organic molecules by 1D and 2D analysis Chemdraw version 7 (www.chemoffice.com for a free
version (version 4 or 5)) Chem 3D
version 7 (www.chemoffice.com for a free version (version 4 or
5)) Bruker X-Win NMR 3.5 (or mestrec-C) Biochemistry and
molecular biology / Microbiology
Good
sterile technique, preparing liquid media, growing up E. coli, growing
up Streptomyces, colony picking Isolation
of genomic DNA, Design of PCR primers, optimization of PCR reaction
conditions Plasmid
purification, agarose gel electrophoresis, restriction
enzyme digests, DNA ligation reactions Preparation
of libraries of mutant enzymes using directed evolution techniques Protein
purification using nickel affinity, anion exchange, hydrophobic interaction,
using AKTA purifier systems SDS PAGE
gel preparation and running Enzyme
kinetic assays by using UV-spectrophotometric
analysis or HPLC analysis 1H NMR analysis of proteins and
enzymes DNA strider
v1.4 Softmax Pro version 4 Digidoc IT gel analysis software Amersham AKTA unicorn software Grafit 5.0 Swiss pdb viewer (http://ca.expasy.org/spdbv/) VMD (http://www.ks.uiuc.edu/Research/vmd/)
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