Research

 Two-photon photocages:

Photomanipulation of cellular chemistry using caged compounds provides a uniquely powerful means to interrogate a wide range of cellular processes. Such photo- manipulation is even more effective using two-photon chemistry, which allows the use of biocompatible, red wavelengths for the photoiniation event. In our lab, we are investigating the synthesis and the two-photon chemistry of simple organic chromophores, such as thiohydroxamic acids, that release biologically active agents such as hydroxyl radicals and nitric oxide.

Biological Radicals:

Guided by a thermodynamic cycle developed in our group, computational, synthetic and laser techniques are being used to further examine the ionization of leaving groups from beta-substituted radicals of biologically important compounds.

Anti-bacterial and anti-pollutant solid-state materials:

Using zeolites as hosts for photochemical precursors to reactive oxygen species has great potential in the development of materials with medicinal and environmental applications, such as anti-bacterial agents and degradation of pollutants. Our group is currently actively pursuing a wide range of strategies in these areas.

Allene Oxide Chemistry

Vinyl allene oxides are important intermediates in both biological and synthetic chemistry. We are continuing out contributions to allene oxide chemistry using photochemical methods to generate and study the chemistry of these elusive intermediates.

We currently have several research projects available for undergraduate and graduate students. If you would like more information on the joining our laboratory please contact us at fcozens@dal.ca or nschepp@dal.ca.

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