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RNAi vs. HIV Papers
Papers appearing
in the Featured Experiments Section:
Lentiviral siRNAs targeting multiple highly conserved RNA sequences of
human immunodeficiency virus type 1.
Lentiviral-mediated delivery of combined HIV-1 decoy TAR and Vif siRNA as
a single RNA molecule that cleaves to inhibit HIV-1 in transduced cells.
HIV-1 resistance
conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a
bispecific lentiviral vector.
Expression of small hairpin RNA by lentivirus-based vector confers
efficient and stable gene-suppression of HIV-1 on human cells including
primary non-dividing cells.
Computational Design of Antiviral RNA Interference Strategies That Resist
Human Immunodeficiency Virus Escape.
Papers appearing
in the Difficulties Section:
The heterosexual human immunodeficiency virus type 1 epidemic in Thailand
is caused by an intersubtype (A/E) recombinant of African origin.
Human
Immunodeficiency Virus Type 1 Escape from RNA Interference.
HIV-1
can escape from RNA Interference by evolving an alternative structure in
its RNA genome.
Induction of an
interferon response by RNAi vectors in mammalian cells.
Short interfering RNAs can induce unexpected and divergent changes in the
levels of untargeted proteins in mammalian cells.
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